High-Resolution Episcopic Microscopy (HREM) / Products
High-Resolution Episcopic Microscopy (HREM) Systems
Optical HREM Platforms for Reproducible 3D Block-Face Imaging
Optical High-Resolution Episcopic Microscopy (OHREM) Systems by Indigo Scientific
Indigo Scientific designs and manufactures Optical High-Resolution Episcopic Microscopy (OHREM) systems engineered specifically for serial block face imaging. Our platforms are built for micron-scale volumetric acquisition, controlled section thickness and reproducible geometric fidelity across a wide range of applications.
System Comparison
Two dedicated HREM platforms are available depending on throughput, specimen size and research requirements.
Feature | OHREM Micro | OHREM Ultra |
|---|---|---|
Intended use | Routine imaging | High-throughput & core facilities |
Intended sample size & quantity | Single sample per run (typically 1–15 mm) | Multiple or larger samples (1–25 mm typical) |
XY & Scanning | Optional XY stage for sample positioning and scanning | Advanced scanning configurations for multi-sample and high-resolution acquisition |
Throughput | Standard acquisition runs | Extended runs and multiple samples |
Fluorescence | Optional second channel (e.g. Lac-Z) | Dual-channel standard, expandable up to four channels with optical sectioning options |
Optical HREM Micro
The Optical HREM micro is a bench top system designed for routine HREM imaging, which is suitable for embryos and smaller organs and medium-scale biological specimens. The system supports straightforward acquisition workflows while maintaining consistent section-to-section alignment.
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Simple acquisition workflow, ideal for smaller laboratories
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Optimised for specimens between 1-15mm
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Upgrades such as extra fluorescence channels and XY scanning available
Optical HREM Ultra
The Optical HREM Ultra is Indigo Scientific’s high-performance HREM platform, developed for high-throughput environments and extended imaging projects. It is designed for larger specimens, multi-sample runs and advanced experimental configurations
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Advanced scanning configurations for extended fields of view or increased resolution
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Multi-sample acquisition capability for large-scale phenotyping
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Modular optical configurations with expandable fluorescence channels
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Electronic focus control for consistent adjustment between samples
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Designed for imaging cores and long-duration acquisition workflows
HREM Consumables & Accessories
A range of dedicated HREM consumables and accessories are available to support routine and high-throughput workflows:
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Precision blades
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PTFE moulds for sample production
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Sample holders for multiple samples and custom configurations
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Replacement components and custom setups
OHREM Specifications
Specifications may vary depending on system configuration and application requirements. Typical baseline parameters include:
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Section thickness range: 1–8 µm (defines axial resolution)
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20-megapixel image capture across variable fields of view (approximately 25 mm to 1 mm X/Y)
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Micro maximum sample size: up to 25 mm × 25 mm × 25 mm
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Ultra maximum sample size: up to 70 mm × 70 mm × 35 mm (expandable with additional hardware)
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File output formats: TIFF, TIF, BMP, PNG, JPEG
Our Products
Contact our team
To discuss your imaging requirements, compare system configurations or request detailed specifications, contact our team to explore the appropriate HREM platform for your application
Phone:
+44(0) 1462633500
Email:
hello@indigo-scientific.co.uk