High-Resolution Episcopic Microscopy (HREM) / Examples

High-Resolution Episcopic Microscopy (HREM) Examples

Example applications for the High-Resolution Episcopic Microscopy technique

HREM Examples Across Biological and Developmental Samples

Below are examples of data produced using our High-Resolution Episcopic Microscopy (HREM) systems, together with images of instruments used by our team and our users.

HREM provides high-contrast, 3D imaging of whole biological samples, making it ideal for embryos, organs, and soft tissues where detailed anatomical reconstruction is required. Image resolution and dataset size depend on system configuration and sample type, with individual sections reaching up to 20 megapixels.

Videos are displayed at reduced resolution for clarity and accessibility.

For application-specific examples or feasibility discussions, please contact us.

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Cardiovascular · Mouse · HREM Case Study

Mouse Embryonic Heart

Mouse heart imaged with optical hrem 3D system

RAW HREM Image

A 2D RAW captured HREM image captured at the block face, a single shot, downsized image from 3 micron data.

3D HREM heart cropped to see inner valves and structures

3D Reconstruction Frame

Images inverted and planes cut to reveal subtle ventricle details at high contrast.

3D Video Export

Using Dragonfly a 3D render was created showing fly throughs and detail of the mouse embryo heart captured on the OHREM system.

Whole mouse embryonic heart imaged using High-Resolution Episcopic Microscopy at 3µm voxel resolution. The dataset was acquired as a complete image stack, producing an inherently aligned 3D volume from which any cross-sectional plane can be extracted retrospectively.

The cross-sectional view reveals internal cardiac architecture such as chamber walls, septal structures, and developing valve regions are clearly resolved. The 3D model demonstrates complete external morphology, with HREM preserving tissue geometry without the distortion associated with optical clearing.

Heart Imaging Page